Comment on: Relationship of Serum Magnesium and Vitamin D Levels in a Nationally-representative Sample of Iranian Adolescents: The CASPIAN-III Study

DEAR EDITOR, We read with great interest, the published article entitled “relationship of serum magnesium and Vitamin D levels in a nationally-representative sample of Iranian adolescents; the CASPIAN-III study” by Kelishadi et al. They aimed, to assess the association of serum magnesium and Vitamin D (25(OH) D) levels in 330 students, aged range from 10 to 18 years. At this study, they found the significant association of magnesium with 25(OH) D serum levels. They suggested further considerations to find the underlying mechanisms and the clinical significance of the current findings. At this study, we would like to point out a few notes. In a cross-sectional investigation on a 41 patients of end-stage renal failure on regular hemodialysis, we found a significant positive correlation of serum magnesium with 25 OH Vitamin D (r = 0.40, P = 0.009). This significant association was strongly positive in nondiabetic, diabetic, females, and male groups individually. Recently, Gandhe et al., conducted a study to find out the probable correlation of Vitamin D3, and magnesium levels in Type II diabetes mellitus cases. They firstly observed low magnesium levels in Type II diabetes mellitus subjects, as compared to healthy controls and secondly, 1Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran, 1Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, 2Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharhekord, Iran Correspondence to: Prof. Mahmoud Rafi eian-Kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharhekord, Iran. E-mail: rafi [email protected]